Radius additivity score: a novel combination index for tumour growth inhibition in fixed-dose xenograft studies.

ABSTRACT: The effect of combination therapies in many cancers has often been shown to be superior to that of monotherapies. This success is commonly attributed to drug synergies. Combinations of two (or more) drugs in xenograft tumor growth inhibition (TGI) studies are typically designed at fixed doses for each compound. The available methods for assessing synergy in such study designs are based on combination indices (CI) and model-based analyses. The former methods are suitable for screening exercises but are difficult to verify in in vivo studies, while the latter incorporate drug synergy in semi-mechanistic frameworks describing disease progression and drug action but are unsuitable for screening. In the current study, we proposed the empirical radius additivity (Rad-add) score, a novel CI for s

SUBMITTER: Melillo N 

PROVIDER: S-EPMC10603293 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature