Ceftriaxone and the Risk of Ventricular Arrhythmia, Cardiac Arrest, and Death Among Patients Receiving Lansoprazole.

ABSTRACT:

Importance

The combination of ceftriaxone and lansoprazole has been shown to prolong the corrected QT interval on electrocardiogram. However, it is unknown whether this translates to clinically important patient outcomes.

Objective

To compare lansoprazole with another proton pump inhibitor (PPI) during ceftriaxone treatment in terms of risk for ventricular arrhythmia, cardiac arrest, and in-hospital mortality.

Design, setting, and participants

A retrospective cohort study including adult medical inpatients receiving ceftriaxone with lansoprazole or another PPI in 13 hospitals in Ontario, Canada, was conducted from January 1, 2015, to December 31, 2021.

Exposure

Lansoprazole during ceftriaxone treatment vs other PPIs during ceftriaxone treatment.

Main outcome

SUBMITTER: Bai AD 

PROVIDER: S-EPMC10603497 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature