Obesity and metabolic syndrome are associated with short-term endocrine therapy resistance in early ER + breast cancer.

ABSTRACT:

Purpose

Increased body mass index (BMI) and metabolic syndrome (MS) are associated with increased breast cancer recurrence risk. Whether this is due to intrinsic tumor biology or modifiable factors of the obese state remains incompletely understood.

Methods

Oncotype DX Recurrence Scores of 751 patients were stratified by BMI to assess association with tumor-intrinsic recurrence risk. Cellular proliferation by Ki67 after 10-21 days of presurgical letrozole treatment was used to stratify endocrine therapy response (sensitive-ln(Ki67) < 1; intermediate-ln(Ki67)1-2; resistant-ln(Ki67) >  = 2). BMI at the time of surgery and MS variables were collected retrospectively for 143 patients to analyze association between therapy response and BMI/MS. Additionally, PI3K pathway signaling

SUBMITTER: Bergman R 

PROVIDER: S-EPMC10603601 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature