Novel Heredity Basis of the Four-Horn Phenotype in Sheep Using Genome-Wide Sequence Data.

ABSTRACT: Horns are an important breeding trait for sheep. However, no widely recognized viewpoint on the regulatory genes and mechanisms of horns is available, and the genetic basis of the four-horn phenotype (FHP) is unclear. This work conducted a genome-wide association study with 100 sheep genomes from multiple breeds to investigate the genetic basis of the FHP. The results revealed three significant associations (corrected as p < 1.64 × 10^-8) of the InDels (CHR2: g.133,742,709delA, g.133,743,215insC, and g.133,743,940delT) for FHP in the intergenic sequence (IGS) between the MTX2 and the LOC105609047 of CHR2. Moreover, 14 significant associations (corrected as p < 1.42 × 10^-9) of SNPs with the FHP phenotype were identified in CHR2 and CHR16, inc

SUBMITTER: Zhang H 

PROVIDER: S-EPMC10603714 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature