Coumarin Dimer Is an Effective Photomechanochemical AND Gate for Small-Molecule Release.

ABSTRACT: Stimulus-responsive gating of chemical reactions is of considerable practical and conceptual interest. For example, photocleavable protective groups and gating mechanophores allow the kinetics of purely thermally activated reactions to be controlled optically or by mechanical load by inducing the release of small-molecule reactants. Such release only in response to a sequential application of both stimuli (photomechanochemical gating) has not been demonstrated despite its unique expected benefits. Here, we describe computational and experimental evidence that coumarin dimers are highly promising moieties for realizing photomechanochemical control of small-molecule release. Such dimers are transparent and photochemically inert at wavelengths >300 nm but can be made to dissociate rapidly und

SUBMITTER: He X 

PROVIDER: S-EPMC10603814 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature