Bone Morphogenic Proteins and Their Antagonists in the Lower Airways of Stable COPD Patients.

ABSTRACT:

Background

Bone morphogenic proteins (BMPs) and their antagonists are involved in the tissue development and homeostasis of various organs.

Objective

To determine transcriptomic and protein expression of BMPs and their antagonists in stable COPD.

Methods

We measured the expression and localization of BMPs and some relevant antagonists in bronchial biopsies of stable mild/moderate COPD (MCOPD) (n = 18), severe/very severe COPD (SCOPD) (n = 16), control smokers (CS) (n = 13), and control non-smokers (CNS) (n = 11), and in lung parenchyma of MCOPD (n = 9), CS (n = 11), and CNS (n = 9) using immunohistochemistry and transcriptome analysis, in vitro after the stimulation of the 16HBE cells.

Results

In bronchial biopsies, BMP4 antagonists CRIM1 and chordin were incre

SUBMITTER: Di Stefano A 

PROVIDER: S-EPMC10603834 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature