Simultaneous Nanorheometry and Nanothermometry Using Intracellular Diamond Quantum Sensors.

ABSTRACT: The viscoelasticity of the cytoplasm plays a critical role in cell morphology, cell division, and intracellular transport. Viscoelasticity is also interconnected with other biophysical properties, such as temperature, which is known to influence cellular bioenergetics. Probing the connections between intracellular temperature and cytoplasmic viscoelasticity provides an exciting opportunity for the study of biological phenomena, such as metabolism and disease progression. The small length scales and transient nature of changes in these parameters combined with their complex interdependencies pose a challenge for biosensing tools, which are often limited to a single readout modality. Here, we present a dual-mode quantum sensor capable of performing simultaneous nanoscale thermometry and rheo

SUBMITTER: Gu Q 

PROVIDER: S-EPMC10604098 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature