Dynamics of Liver Macrophage Subsets in a Novel Mouse Model of Non-Alcoholic Steatohepatitis Using C57BL/6 Mice.

ABSTRACT: Macrophages are critical for the development of non-alcoholic steatohepatitis (NASH). Our previous findings in TSNO mouse livers showed that an iHFC (high-fat/cholesterol/cholate) diet induced liver fibrosis similar to human NASH and led to the accumulation of distinct subsets of macrophage: CD11c⁺/Ly6C^- and CD11c^-/Ly6C⁺ cells. CD11c⁺/Ly6C^- cells were associated with the promotion of advanced liver fibrosis in NASH. On the other hand, CD11c^-/Ly6C⁺ cells exhibited an anti-inflammatory effect and were involved in tissue remodeling processes. This study aimed to elucidate whether an iHFC diet with reduced cholic acid (iHFC#2 diet) induces NASH in C57BL/6 mice and examine the macrophage subsets accumulating

SUBMITTER: Makiuchi N 

PROVIDER: S-EPMC10604124 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature