Gingival Fibroblasts Are Sensitive to Oral Cell Lysates Indicated by Their IL11 Expression.

ABSTRACT: Damaged cells that appear as a consequence of invasive dental procedures or in response to dental materials are supposed to release damage-associated signals. These damage-associated signals not only support tissue regeneration but might also contribute to unwanted fibrosis. The aim of this study was to identify a molecular target that reflects how fibroblasts respond to necrotic oral tissue cells. To simulate the cell damage, we prepared necrotic cell lysates by sonication of the osteocytic cell line IDG-SW3 and exposed them to gingival fibroblasts. RNAseq revealed a moderate increase in IL11 expression in the gingival fibroblasts, a pleiotropic cytokine involved in fibrosis and inflammation, and also in regeneration following trauma. Necrotic lysates of the human squamous carcinoma cell

SUBMITTER: Panahipour L 

PROVIDER: S-EPMC10604186 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature