Genetic Modulation of HPV Infection and Cervical Lesions: Role of Oxidative Stress-Related Genes.

ABSTRACT: Human papillomavirus (HPV) infection is a necessary but not sufficient factor for the development of invasive cervical cancer (ICC) and high-grade intraepithelial lesion (HSIL). Oxidative stress is known to play a crucial role in HPV infection and carcinogenesis. In this study, we comprehensively investigate the modulation of HPV infection, HSIL and ICC, and ICC through an exploration of oxidative stress-related genes: CβS, MTHFR, NOS3, ACE1, CYBA, HAP, ACP1, GSTT1, GSTM1, and CYP1A1. Notably, the ACE1 gene emerges as a prominent factor with the presence of the I allele offering protection against HPV infection. The association of NOS3 with HPV infection is perceived with the 4a allele showing a protective

SUBMITTER: Inacio A 

PROVIDER: S-EPMC10604255 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature