Implications for Combination Therapy of Selective Monoamine Reuptake Inhibitors on Dopamine Transporters.

ABSTRACT: Monoamine transporters, including dopamine, norepinephrine, and serotonin transporters (DAT, NET, and SERT, respectively), are important therapeutic targets due to their essential roles in the brain. To overcome the slow action of selective monoamine reuptake inhibitors, dual- or triple-acting inhibitors have been developed. Here, to examine whether combination treatments of selective reuptake inhibitors have synergistic effects, the pharmacological properties of DAT, NET, and SERT were investigated using the selective inhibitors of each transporter, which are vanoxerine, nisoxetine, and fluoxetine, respectively. Potencies were determined via fluorescence-based substrate uptake assays in the absence and presence of other inhibitors to test the multi-drug effects on individual transporters,

SUBMITTER: Ahn H 

PROVIDER: S-EPMC10604324 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature