Predicting stringent QuantiFERON-TB Gold Plus conversions in contacts of tuberculosis patients.

ABSTRACT:

Objectives

To assess associations between disease severity in index TB patients and QuantiFERON-TB Gold Plus (QFT-Plus) results in contacts, and predictors for QFT-Plus conversion in contacts over 6-12 months.

Methods

TB patients (n = 295) and the contacts (n = 1051) were enrolled during 2018-2021 with QFT-Plus performed at baseline and months 6 and 12. A strong CD8 response was defined as TB2 interferon gamma (IFN-γ) response minus TB1 >0.6 IU/ml and stringent conversion as change from QFT-plus negative to high-positive QFT-Plus (TB1 or TB2 IFN-γ responses >0.7 IU/ml).

Results

Contacts with index TB patients with sputum smear >1+ was associated with positive QFT-Plus compared to those without (p < 0.001). Contacts with index TB patients with bilateral lung disease we

SUBMITTER: Pan SW 

PROVIDER: S-EPMC10604336 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature