KDM2A Deficiency in the Liver Promotes Abnormal Liver Function and Potential Liver Damage.

ABSTRACT: Dysregulation of metabolic functions in the liver impacts the development of diabetes and metabolic disorders. Normal liver function can be compromised by increased inflammation via the activation of signaling such as nuclear factor (NF)-κB signaling. Notably, we have previously identified lysine demethylase 2A (KDM2A)-as a critical negative regulator of NF-κB. However, there are no studies demonstrating the effect of KDM2A on liver function. Here, we established a novel liver-specific Kdm2a knockout mouse model to evaluate KDM2A's role in liver functions. An inducible hepatic deletion of Kdm2a, Alb-Cre-Kdm2a^fl/fl (Kdm2a KO), was generated by crossing the Kdm2a floxed mice (Kdm2a^fl/fl) we established with commercial albumin-Cre trans

SUBMITTER: Martin M 

PROVIDER: S-EPMC10604476 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature