TiO₂ nanoparticles promote tumor metastasis by eliciting pro-metastatic extracellular vesicles.

ABSTRACT: The development of nanotechnology has provided numerous possibilities for the diagnosis and treatment of cancer. Paradoxically, some in vivo experimental studies have also shown that nanoparticles (NPs) could promote tumor progression, but the specific mechanism is not yet clear. Primary tumors can release extracellular vesicles (EVs) which can promote the inoculation and growth of tumor cells that have metastasized to distant organs. So, whether nanomaterials can promote tumor progression through tumor-derived EVs deserves further research. Here, we showed that TiO₂ NPs, widely used in nanomedicine, could trigger tumor-derived EVs with enhanced pro-metastatic capacity in vitro and in vivo. Mechanically, miR-301a-3p derived from NPs-elicited EVs could be delivered into vascular

SUBMITTER: Mu X 

PROVIDER: S-EPMC10604521 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature