Novel Approaches in Chronic Renal Failure without Renal Replacement Therapy: A Review.

ABSTRACT: Chronic kidney disease (CKD) is characterized by renal parenchymal damage leading to a reduction in the glomerular filtration rate. The inflammatory response plays a pivotal role in the tissue damage contributing to renal failure. Current therapeutic options encompass dietary control, mineral salt regulation, and management of blood pressure, blood glucose, and fatty acid levels. However, they do not effectively halt the progression of renal damage. This review critically examines novel therapeutic avenues aimed at ameliorating inflammation, mitigating extracellular matrix accumulation, and fostering renal tissue regeneration in the context of CKD. Understanding the mechanisms sustaining a proinflammatory and profibrotic state may offer the potential for targeted pharmacological interventi

SUBMITTER: Martinez-Hernandez SL 

PROVIDER: S-EPMC10604533 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature