Comprehensive Analysis of Virulence Determinants and Genomic Islands of bla_NDM-1-Producing Enterobacter hormaechei Clinical Isolates from Greece.

ABSTRACT: Nosocomial outbreaks of multidrug-resistant (MDR) Enterobacter cloacae complex (ECC) are often reported worldwide, mostly associated with a small number of multilocus-sequence types of E. hormaechei and E. cloacae strains. In Europe, the largest clonal outbreak of bla_NDM-1-producing ECC has been recently reported, involving an ST182 E. hormaechei strain in a Greek teaching hospital. In the current study, we aimed to further investigate the genetic make-up of two representative outbreak isolates. Comparative genomics of whole genome sequences (WGS) was performed, including whole genome-based taxonomic analysis and in silico prediction of virulence determinants of the bacterial cell surface, plasmids, antibiotic resistance genes and virulence fac

SUBMITTER: Mavroidi A 

PROVIDER: S-EPMC10604629 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature