USP39-Mediated Non-Proteolytic Control of ETS2 Suppresses Nuclear Localization and Activity.

ABSTRACT: ETS2 is a member of the ETS family of transcription factors and has been implicated in the regulation of cell proliferation, differentiation, apoptosis, and tumorigenesis. The aberrant activation of ETS2 is associated with various human cancers, highlighting its importance as a therapeutic target. Understanding the regulatory mechanisms and interacting partners of ETS2 is crucial for elucidating its precise role in cellular processes and developing novel strategies to modulate its activity. In this study, we conducted binding assays using a human deubiquitinase (DUB) library and identified USP39 as a novel ETS2-binding DUB. USP39 interacts with ETS2 through their respective amino-terminal regions, and the zinc finger and PNT domains are not required for this binding. USP39 deubiquitinates

SUBMITTER: Choi Y 

PROVIDER: S-EPMC10604658 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature