Metabolic modulation of mitochondrial mass during CD4⁺ T cell activation.

ABSTRACT: Mitochondrial biogenesis initiates within hours of T cell receptor (TCR) engagement and is critical for T cell activation, function, and survival; yet, how metabolic programs support mitochondrial biogenesis during TCR signaling is not fully understood. Here, we performed a multiplexed metabolic chemical screen in CD4⁺ T lymphocytes to identify modulators of metabolism that impact mitochondrial mass during early T cell activation. Treatment of T cells with pyrvinium pamoate early during their activation blocks an increase in mitochondrial mass and results in reduced proliferation, skewed CD4⁺ T cell differentiation, and reduced cytokine production. Furthermore, administration of pyrvinium pamoate at the time of induction of experimental autoimmune encephalomyelitis, a

SUBMITTER: Kurmi K 

PROVIDER: S-EPMC10604707 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature