Enabling mRNA Therapeutics: Current Landscape and Challenges in Manufacturing.

ABSTRACT: Recent advances and discoveries in the structure and role of mRNA as well as novel lipid-based delivery modalities have enabled the advancement of mRNA therapeutics into the clinical trial space. The manufacturing of these products is relatively simple and eliminates many of the challenges associated with cell culture production of viral delivery systems for gene and cell therapy applications, allowing rapid production of mRNA for personalized treatments, cancer therapies, protein replacement and gene editing. The success of mRNA vaccines during the COVID-19 pandemic highlighted the immense potential of this technology as a vaccination platform, but there are still particular challenges to establish mRNA as a widespread therapeutic tool. Immunostimulatory byproducts can pose a barrier for

SUBMITTER: Youssef M 

PROVIDER: S-EPMC10604719 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature