A Desmethylphosphinothricin Dipeptide Derivative Effectively Inhibits Escherichia coli and Bacillus subtilis Growth.

ABSTRACT: New antibiotics are unquestionably needed to fight the emergence and spread of multidrug-resistant bacteria. To date, antibiotics targeting bacterial central metabolism have been poorly investigated. By determining the minimal inhibitory concentration (MIC) of desmethylphosphinothricin (Glu-γ-P_H), an analogue of glutamate with a phosphinic moiety replacing the γ-carboxyl group, we previously showed its promising antibacterial activity on Escherichia coli. Herein, we synthetized and determined the growth inhibition exerted on E. coli by an L-Leu dipeptide derivative of Glu-γ-P_H (L-Leu-D,L-Glu-γ-P_H). Furthermore, we compared the growth inhibition obtained with this dipeptide with that exerted by the free amino acid, i

SUBMITTER: Khomutov MA 

PROVIDER: S-EPMC10604730 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature