Differential regulation of nucleus accumbens glutamate and GABA in obesity-prone and obesity-resistant rats.

ABSTRACT: Obesity is one of the leading health concerns in the United States. Studies from human and rodent models suggest that inherent differences in the function of brain motivation centers, including the nucleus accumbens (NAc), contribute to overeating and thus obesity. For example, there are basal enhancements in the excitability of NAc GABAergic medium spiny neurons (MSN) and reductions in basal expression of AMPA-type glutamate receptors in obesity-prone vs obesity-resistant rats. However, very little is known about the regulation of extracellular glutamate and GABA within the NAc of these models. Here we gave obesity-prone and obesity-resistant rats stable isotope-labeled glucose (¹³ C₆ -glucose) and used liquid chromatography mass spectrometry (LC-MS) analysis of NAc

SUBMITTER: Vollbrecht PJ 

PROVIDER: S-EPMC10604761 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature