Inorganic Nanoparticles: Tools to Emphasize the Janus Face of Amphotericin B.

ABSTRACT: Amphotericin B is the oldest antifungal molecule which is still currently widely used in clinical practice, in particular for the treatment of invasive diseases, even though it is not devoid of side effects (particularly nephrotoxicity). Recently, its redox properties (i.e., both prooxidant and antioxidant) have been highlighted in the literature as mechanisms involved in both its activity and its toxicity. Interestingly, similar properties can be described for inorganic nanoparticles. In the first part of the present review, the redox properties of Amphotericin B and inorganic nanoparticles are discussed. Then, in the second part, inorganic nanoparticles as carriers of the drug are described. A special emphasis is given to their combined redox properties acting either as a prooxidant or a

SUBMITTER: Boudier A 

PROVIDER: S-EPMC10604816 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature