In Vitro microRNA Expression Profile Alterations under CDK4/6 Therapy in Breast Cancer.

ABSTRACT:

Background

Breast cancer is the most common type of cancer worldwide. Cyclin-dependent kinase inhibition is one of the backbones of metastatic breast cancer therapy. However, there are a significant number of therapy failures. This study evaluates the biomarker potential of microRNAs for the prediction of a therapy response under cyclin-dependent kinase inhibition.

Methods

This study comprises the analysis of intracellular and extracellular microRNA-expression-level alterations of 56 microRNAs under palbociclib mono as well as combination therapy with letrozole. Breast cancer cell lines BT-474, MCF-7 and HS-578T were analyzed using qPCR.

Results

A palbociclib-induced microRNA signature could be detected intracellularly as well as extracellularly. Intracellular miR-10a

SUBMITTER: Asberger J 

PROVIDER: S-EPMC10604872 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature