Determinants of immunosuppressive therapy in renal transplant recipients: an Italian observational study (the CESIT project).

ABSTRACT:

Background

Very scanty evidence is available on factors influencing the choice of immunosuppressive drug therapy after kidney transplantation.

Methods

An Italian multiregional real-world study was conducted integrating national transplant information system and claims data. All patients undergoing kidney transplantation for the first time during 2009-2019 (incident patients) were considered. Multilevel logistic models were used to estimate Odds Ratio (OR) and corresponding 95% Confidence intervals. Factors with statistically significance were identified as characteristics associated with treatment regimens: cyclosporin-CsA vs tacrolimus-Tac and, within the latter group, mTOR inhibitors vs mycophenolate-MMF.

Results

We identified 3,622 kidney patients undergoing transp

SUBMITTER: Rosa AC 

PROVIDER: S-EPMC10604923 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature