Prognostic Significance of Cyclin D1 Expression in Small Intestinal Adenocarcinoma.

ABSTRACT: Cyclin D1, a critical cyclin-dependent kinase (CDK) 4/6-dependent regulator of G1/S transition, has attracted much interest as a therapeutic target. The cyclin D1 expression in small intestinal adenocarcinomas (SIACs) has not yet been comprehensively studied, owing to the rarity of this tumor. We investigated the clinicopathological and prognostic significance of the cyclin D1 expression in 232 surgically resected primary SIACs through a multi-institutional study. A high expression of cyclin D1 (cyclin D1^High) was detected in 145 SIAC cases (63%), which was significantly higher than that in normal small intestinal mucosa (11%). Cyclin D1^High was more commonly found in SIACs with a lower T-category and disease stage and KRAS mutation and predicted better patient

SUBMITTER: Jun SY 

PROVIDER: S-EPMC10604933 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature