Novel Therapeutic Strategies Exploiting the Unique Properties of Neuroendocrine Neoplasms.

ABSTRACT:

Background

Over the last few decades of treatment, the outcomes for at least some subsets of neuroendocrine neoplasms (NENs) have improved. However, the identification of new vulnerabilities for this heterogeneous group of cancers remains a priority.

Methods

Using two libraries of compounds selected for potential repurposing, we identified the inhibitors of nicotinamide phosphoribosyltransferase (NAMPT) and histone deacetylases (HDAC) as the agents with the highest activity. We validated the hits in an expanded set of neuroendocrine cell lines and examined the mechanisms of action.

Results

In Kelly, NH-6, and NCI-H82, which are two neuroblastoma and one small cell lung cancer cell lines, respectively, metabolic studies suggested that cell death following NAMPT inhibit

SUBMITTER: Safari M 

PROVIDER: S-EPMC10605125 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature