A Combinatorial Regulatory Platform Determines Expression of RNA Polymerase III Subunit RPC7α (<i>POLR3G</i>) in Cancer.

ABSTRACT: RNA polymerase III (Pol III) subunit RPC7α, which is encoded by POLR3G in humans, has been linked to both tumor growth and metastasis. Accordantly, high POLR3G expression is a negative prognostic factor in multiple cancer subtypes. To date, the mechanisms underlying POLR3G upregulation have remained poorly defined. We performed a large-scale genomic survey of mRNA and chromatin signatures to predict drivers of POLR3G expression in cancer. Our survey uncovers positive determinants of POLR3G expression, including a gene-internal super-enhancer bound with multiple transcription factors (TFs) that promote POLR3G expression, as well as negative determinants that include gene-internal DNA methylation, retinoic-acid induced differentiation, and MXD4-media

SUBMITTER: Cheng R 

PROVIDER: S-EPMC10605170 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature