Astrocytes Undergo Metabolic Reprogramming in the Multiple Sclerosis Animal Model.

ABSTRACT: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system that presents a largely unknown etiopathology. The presence of reactive astrocytes in MS lesions has been described for a long time; however, the role that these cells play in the pathophysiology of MS is still not fully understood. Recently, we used an MS animal model to perform high-throughput sequencing of astrocytes' transcriptome during disease progression. Our data show that astrocytes isolated from the cerebellum (a brain region typically affected in MS) showed a strong alteration in the genes that encode for proteins related to several metabolic pathways. Specifically, we found a significant increase in glycogen degradation, glycolytic, and TCA cycle enzymes. Together with these alterations, we

SUBMITTER: das Neves SP 

PROVIDER: S-EPMC10605171 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature