Interaction between Genetic Risks and Socioeconomic Factors on Thyroid Cancer: Evidence from 0.5 Million UK Biobank Participants.

ABSTRACT:

Background

There is a research gap between genetic predisposition, socioeconomic factors, and their interactions on thyroid tumorigenesis.

Methods

Individual and genetic data were obtained from UK Biobank. Logistic regression models were used to evaluate the association between genetic risk, socioeconomic factors, and thyroid cancer (TCa). A stratified analysis was conducted to estimate their joint effects. A two-sample Mendelian randomization (MR) analysis was further used to examine the potential causality.

Results

A total of 502,394 participants were included in this study. Three index loci (rs4449583, rs7726159, and rs7725218) of telomerase reverse transcriptase (TERT) were found to be significantly related to incident TCa. Association analyses showed that

SUBMITTER: Li Y 

PROVIDER: S-EPMC10605197 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature