Extremophilic Solutions: The Role of Deinoxanthin in Counteracting UV-Induced Skin Harm.

ABSTRACT: This research delved into the protective capacities of deinoxanthin, a carotenoid present in Deinococcus radiodurans, against UVA- and UVB-mediated skin damage using human fibroblast foreskin cells (HFF-1). Using the MTT assay, HFF-1 cells treated with 10 µM DNX displayed 20% and 31.7% higher viability than the positive (Vitamin C-treated) and negative (DNX-untreated) control groups, respectively, upon 100 mJ/cm² UVB exposure. At 24 J/cm² UVA, 20 µM DNX-treated cells showed 80.6% viability, exceeding the positive and negative control groups by 28.6% and 33.6%, respectively. Flow cytometry analysis revealed that cells treated with DNX and exposed to 24 J/cm² UVA exhibited a 69.32% reduction in apoptotic processes compared to untreated cells. Similarly, when

SUBMITTER: Kuzucu M 

PROVIDER: S-EPMC10605247 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature