Protein Lactylation Modification and Proteomics Features in Cirrhosis Patients after UC-MSC Treatment.

ABSTRACT: Umbilical cord mesenchymal stem cell (UC-MSC) therapy improves liver function in liver cirrhosis patients. This study aimed to elucidate the therapeutic mechanism underlying cell therapy by analyzing changes in the modification and expression of proteins 1 month post-treatment with UC-MSCs. This prospective study included 11 cirrhosis patients who received MSC injection. The laboratory indexes before and after treatment were collected to evaluate the clinical treatment effect of UC-MSCs, and the protein expression and lactylation modification in the liver were comprehensively revealed. Meanwhile, weighted gene co-expression network analysis was used to analyze the co-expression protein modules and their relationship with clinical features. The patients with liver cirrhosis showed an improv

SUBMITTER: Xie Y 

PROVIDER: S-EPMC10605309 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature