Cross-Talks between RKIP and YY1 through a Multilevel Bioinformatics Pan-Cancer Analysis.

ABSTRACT: Recent studies suggest that PEBP1 (also known as RKIP) and YY1, despite having distinct molecular functions, may interact and mutually influence each other's activity. They exhibit reciprocal control over each other's expression through regulatory loops, prompting the hypothesis that their interplay could be pivotal in cancer advancement and resistance to drugs. To delve into this interplay's functional characteristics, we conducted a comprehensive analysis using bioinformatics tools across a range of cancers. Our results confirm the association between elevated YY1 mRNA levels and varying survival outcomes in diverse tumors. Furthermore, we observed differing degrees of inhibitory or activating effects of these two genes in apoptosis, cell cycle, DNA damage, and other cancer pathways, alo

SUBMITTER: Baritaki S 

PROVIDER: S-EPMC10605344 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature