Novel Insights on the Role of Epigenetics in Androgen Receptor's Expression in Prostate Cancer.

ABSTRACT: The androgens/androgen receptor (AR) axis is the main therapeutic target in prostate cancer (PCa). However, while initially responsive, a subset of tumors loses AR expression through mechanisms putatively associated with epigenetic modifications. In this study, we assessed the link between the presence of CpG methylation in the 5'UTR and promoter regions of AR and loss of AR expression. Hence, we characterized and compared the methylation signature at CpG resolution of these regulatory regions in vitro, both at basal levels and following treatment with 5-aza-2-deoxycytidine (DAC) alone, or in combination with Trichostatin A (TSA). Our results showed heterogeneity in the methylation signature of AR negative cell lines and pinpointed the proximal promoter region as the most consistently meth

SUBMITTER: Camilo V 

PROVIDER: S-EPMC10605369 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature