The Carcinogenic Potential of Bisphenol A in the Liver Based on Transcriptomic Studies.

ABSTRACT: Bisphenol A (BPA) is an environmental toxin widely used in the production of polycarbonate plastics. A correlation exists between BPA tissue contamination and the occurrence of pathological conditions, including cancer. First-passage detoxification of high BPA amounts in the liver promotes hepatotoxicity and morphological alterations of this organ, but there is a lack of knowledge about the molecular mechanisms underlying these phenomena. This prompted us to investigate changes in the liver transcriptomics of 3-month-old female mice exposed to BPA (50 mg/kg) in drinking water for 3 months. Five female mice served as controls. The animals were euthanized, the livers were collected, and RNA was extracted to perform RNA-seq analysis. The multistep transcriptomic bioinformatics revealed 120 di

SUBMITTER: Wiszpolska M 

PROVIDER: S-EPMC10605469 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature