Decoding the Impact of Tumor Microenvironment in Osteosarcoma Progression and Metastasis.

ABSTRACT: Osteosarcoma (OS) is a heterogeneous, highly metastatic bone malignancy in children and adolescents. Despite advancements in multimodal treatment strategies, the prognosis for patients with metastatic or recurrent disease has not improved significantly in the last four decades. OS is a highly heterogeneous tumor; its genetic background and the mechanism of oncogenesis are not well defined. Unfortunately, no effective molecular targeted therapy is currently available for this disease. Understanding osteosarcoma's tumor microenvironment (TME) has recently gained much interest among scientists hoping to provide valuable insights into tumor heterogeneity, progression, metastasis, and the identification of novel therapeutic avenues. Here, we review the current understanding of the TME of OS, in

SUBMITTER: Nirala BK 

PROVIDER: S-EPMC10605493 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature