PRF Lysates Enhance the Proliferation and Migration of Oral Squamous Carcinoma Cell Lines.

ABSTRACT: Platelet-rich fibrin (PRF) is an autologous fibrin-rich matrix where activated platelets and leucocytes accumulate. PRF has a wide spectrum of clinical indications with the overall aim of supporting tissue regeneration which in dentistry includes the healing of healthy oral mucosa with epithelial cells. In oral squamous cell carcinoma lesions, however, epithelial cells undergo malignant transformation, indicated by their unrestricted proliferation and migration potential, which should not be further enhanced by a wound-healing formula. Yet, little is known about how oral squamous cell carcinomas respond to PRF lysates. The aim of the present study was, therefore, to test the capacity of PRF lysates to change the transcriptome of HSC2 oral squamous carcinoma cells and perform bioassays to s

SUBMITTER: Panahipour L 

PROVIDER: S-EPMC10605502 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature