Spaceflight Induces Strength Decline in Caenorhabditis elegans.

ABSTRACT: Background: Understanding and countering the well-established negative health consequences of spaceflight remains a primary challenge preventing safe deep space exploration. Targeted/personalized therapeutics are at the forefront of space medicine strategies, and cross-species molecular signatures now define the 'typical' spaceflight response. However, a lack of direct genotype-phenotype associations currently limits the robustness and, therefore, the therapeutic utility of putative mechanisms underpinning pathological changes in flight. Methods: We employed the worm Caenorhabditis elegans as a validated model of space biology, combined with 'NemaFlex-S' microfluidic devices for assessing animal strength production as one of the most reproducible physiological response

SUBMITTER: Soni P 

PROVIDER: S-EPMC10605753 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature