Vaginal microbiome, antiretroviral concentrations, and HIV genital shedding in the setting of hormonal contraception initiation in Malawi.

ABSTRACT:

Objective

The aim of this study was to understand how vaginal microbiota composition affects antiretroviral concentrations in the setting of hormonal contraception initiation.

Methods

Cervicovaginal fluid (CVF) concentrations of tenofovir, lamivudine, and efavirenz from 73 Malawian women with HIV were compared before and after initiation of depot-medroxyprogesterone acetate (DMPA) or levonorgestrel implant. We evaluated antiretroviral concentrations and vaginal microbiota composition/structure in the context of contraception initiation and predicted genital shedding using multivariable repeated measurements models fit by generalized estimating equations.

Results

Mean lamivudine CVF concentrations decreased 37% 1 month after contraception initiation. Subgroup analyses

SUBMITTER: Lantz AM 

PROVIDER: S-EPMC10605758 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature