Gene expression in notochord and nuclei pulposi: a study of gene families across the chordate phylum.

ABSTRACT: The transition from notochord to vertebral column is a crucial milestone in chordate evolution and in prenatal development of all vertebrates. As ossification of the vertebral bodies proceeds, involutions of residual notochord cells into the intervertebral discs form the nuclei pulposi, shock-absorbing structures that confer flexibility to the spine. Numerous studies have outlined the developmental and evolutionary relationship between notochord and nuclei pulposi. However, the knowledge of the similarities and differences in the genetic repertoires of these two structures remains limited, also because comparative studies of notochord and nuclei pulposi across chordates are complicated by the gene/genome duplication events that led to extant vertebrates. Here we show the results of a pilot

SUBMITTER: Raghavan R 

PROVIDER: S-EPMC10605842 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature