Slc11 Synapomorphy: A Conserved 3D Framework Articulating Carrier Conformation Switch.

ABSTRACT: Transmembrane carriers of the Slc11 family catalyze proton (H⁺)-dependent uptake of divalent metal ions (Me²⁺) such as manganese and iron-vital elements coveted during infection. The Slc11 mechanism of high-affinity Me²⁺ cell import is selective and conserved between prokaryotic (MntH) and eukaryotic (Nramp) homologs, though processes coupling the use of the proton motive force to Me²⁺ uptake evolved repeatedly. Adding bacterial piracy of Nramp genes spread in distinct environmental niches suggests selective gain of function that may benefit opportunistic pathogens. To better understand Slc11 evolution, Alphafold (AF2)/Colabfold (CF) 3D predictions for bacterial sequences from sister clades of eukaryotic descent (MCb and MCg) were compared

SUBMITTER: Cellier MFM 

PROVIDER: S-EPMC10606218 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature