Chitosan Hydrogels Crosslinked with Oxidized Sucrose for Antimicrobial Applications.

ABSTRACT: Oxidized sucrose (OS) reacts with amino-group-containing polysaccharides, including chitosan, without catalyst, resulting in hydrogels entirely composed of carbohydrates. The presence of imine bonds with low structural stabilities and unreacted aldehydes in the structures of these hydrogels hinder their application as biomaterials. Therefore, herein, the chitosan hydrogels (CTSGs) obtained after the crosslinking of chitosan with OS were reduced using sodium borohydride to convert imine bonds to secondary amines and aldehydes to alcohols. The structures of CTSGs were comprehensively characterized using Fourier transform infrared and ¹³C nuclear magnetic resonance spectroscopies, and the results implied that the degree of crosslinking (CR) depended on the OS feed amount used durin

SUBMITTER: Fujita S 

PROVIDER: S-EPMC10606239 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature