Somatic Mutation of the Non-Muscle-Invasive Bladder Cancer Associated with Early Recurrence.

ABSTRACT: Next-generation sequencing (NGS) is widely used in muscle-invasive bladder cancer but has limited use in non-muscle-invasive bladder cancer (NMIBC) due to significant heterogeneity and high cancer-specific survival. Therefore, we evaluated the genomic information of NMIBC and identified molecular alterations associated with tumour recurrence. A total of 43 patients with NMIBC who underwent transurethral resection of the bladder were enrolled. We performed NGS using an Oncomine panel of tumour specimens and blood samples corresponding to each specimen. The somatic mutation results were analysed by pairwise comparison and logistic regression according to the recurrence of bladder tumours within 1 year. The median incidence of genetic variations in 43 tumour samples was 56 variations per samp

SUBMITTER: Yu SH 

PROVIDER: S-EPMC10606398 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature