Molecular Evolution and Protein Structure Variation of Dkk Family.

ABSTRACT: Dkks have inhibitory effects on the Wnt signaling pathway, which is involved in the development of skin and its appendages and the regulation of hair growth. The nucleotide sequences were compared and analyzed to further investigate the relationship between the structure and function of the Dkk gene family and vertebrate epidermal hair. The analysis of the molecular evolution of the Dkk family revealed that the evolution rate of the genes changed significantly after speciation, with the Aves and Reptilia branches showing accelerated evolution. Additionally, positive selection was observed at specific sites. The tertiary structure of the protein was also predicted. The analysis of the functional divergence of the Dkk family revealed that the functional divergence

SUBMITTER: Wen B 

PROVIDER: S-EPMC10606412 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature