Design, Synthesis, and Biological Evaluation of N'-Phenylhydrazides as Potential Antifungal Agents.

ABSTRACT: Fifty-two kinds of N'-phenylhydrazides were successfully designed and synthesized. Their antifungal activity in vitro against five strains of C. albicans (Candida albicans) was evaluated. All prepared compounds showed varying degrees of antifungal activity against C. albicans and their MIC₈₀ (the concentration of tested compounds when their inhibition rate was at 80%), TAI (total activity index), and TSI (total susceptibility index) were calculated. The inhibitory activities of 27/52 compounds against fluconazole-resistant fungi C. albicans 4395 and 5272 were much better than those of fluconazole. The MIC₈₀ values of 14/52 compounds against fluconazole-resistant fungus C. albicans 5122 were less than 4 μg/mL, so it was the mos

SUBMITTER: Zhu P 

PROVIDER: S-EPMC10606473 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature