INPP5D/SHIP1: Expression, Regulation and Roles in Alzheimer's Disease Pathophysiology.

ABSTRACT: Alzheimer's disease (AD) is the most common form of dementia, accounting for approximately 38.5 million cases of all-cause dementia. Over 60% of these individuals live in low- and middle-income countries and are the worst affected, especially by its deleterious effects on the productivity of both patients and caregivers. Numerous risk factors for the disease have been identified and our understanding of gene-environment interactions have shed light on several gene variants that contribute to the most common, sporadic form of AD. Microglial cells, the innate immune cells of the central nervous system (CNS), have long been established as guardians of the brain by providing neuroprotection and maintaining cellular homeostasis. A protein with a myriad of effects on various important signaling

SUBMITTER: Olufunmilayo EO 

PROVIDER: S-EPMC10606568 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature