Fully Automated Production of [⁶⁸Ga]GaFAPI-46 with Gallium-68 from Cyclotron Using Liquid Targets.

ABSTRACT: ⁶⁸Ga-based radiopharmaceuticals are routinely used for PET imaging of multiple types of tumors. Gallium-68 is commonly obtained from ⁶⁸Ge/⁶⁸Ga generators, which are limited in the quantity of activity produced. Alternatively, gallium-68 can easily be produced on a cyclotron using liquid targets. In this study, we optimized the GMP production of [⁶⁸Ga]GaFAPI-46 using gallium-68 produced via a standard medical cyclotron using liquid targets. Starting from the published synthesis and quality control procedures described for other ⁶⁸Ga-based radiopharmaceuticals, we have validated the synthesis process and the analytical methods to test the quality parameters of the final product to be used for routine clinical studies. [⁶⁸Ga]Ga

SUBMITTER: Fonseca AI 

PROVIDER: S-EPMC10606668 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature