Ontology highlight
ABSTRACT:
SUBMITTER: Ortega-Vazquez A
PROVIDER: S-EPMC10606744 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Ortega-Vázquez Alberto A Sánchez-Badajos Salvador S Ramírez-García Miguel Ángel MÁ Alvarez-Luquín Diana D López-López Marisol M Adalid-Peralta Laura Virginia LV Monroy-Jaramillo Nancy N
Genes 20231007 10
Parkinson's disease (PD) pathophysiology includes mitochondrial dysfunction, neuroinflammation, and aging as its biggest risk factors. Mitochondrial DNA copy number (mtDNA-CN) and telomere length (TL) are biological aging markers with inconclusive results regarding their association with PD. A case-control study was used to measure TL and mtDNA-CN using qPCR in PBMCs. PD patients were naive at baseline (T0) and followed-up at one (T1) and two (T2) years after the dopaminergic treatment (DRT). Pl ...[more]