Association between Gastric Cancer and 12 Autoimmune Diseases: A Mendelian Randomization Study.

ABSTRACT:

Background

Whether the positive associations of gastric cancer (GC) with autoimmune diseases are causal has always been controversial. This study aims to estimate the causal relationship between GC and 12 autoimmune diseases by means of Mendelian randomization (MR) analysis.

Methods

After rigorous evaluation, potential candidate single nucleotide polymorphisms (SNPs) for GC and 12 autoimmune diseases were extracted from genome-wide association study (GWAS) datasets. We performed the MR analyses using the inverse variance weighted (IVW) method as the primary approach to the analysis. Three sensitivity analysis methods were added to assess the robustness of the results. In addition, heterogeneity was measured using Cochran's Q-value, and horizontal pleiotropy was assessed usin

SUBMITTER: Wei Q 

PROVIDER: S-EPMC10606764 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature