Autoantibody Profiling and Anti-Kinesin Reactivity in ANCA-Associated Vasculitis.

ABSTRACT: ANCA-associated vasculitides (AAV) are rare autoimmune diseases causing inflammation and damage to small blood vessels. New autoantibody biomarkers are needed to improve the diagnosis and treatment of AAV patients. In this study, we aimed to profile the autoantibody repertoire of AAV patients using in-house developed antigen arrays to identify previously unreported antibodies linked to the disease per se, clinical subgroups, or clinical activity. A total of 1743 protein fragments representing 1561 unique proteins were screened in 229 serum samples collected from 137 AAV patients at presentation, remission, and relapse. Additionally, serum samples from healthy individuals and patients with other type of vasculitis and autoimmune-inflammatory conditions were included to evaluate the specific

SUBMITTER: Mescia F 

PROVIDER: S-EPMC10607136 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature