Mitochondrial sAC-cAMP-PKA Axis Modulates the ΔΨ_m-Dependent Control Coefficients of the Respiratory Chain Complexes: Evidence of Respirasome Plasticity.

ABSTRACT: The current view of the mitochondrial respiratory chain complexes I, III and IV foresees the occurrence of their assembly in supercomplexes, providing additional functional properties when compared with randomly colliding isolated complexes. According to the plasticity model, the two structural states of the respiratory chain may interconvert, influenced by the intracellular prevailing conditions. In previous studies, we suggested the mitochondrial membrane potential as a factor for controlling their dynamic balance. Here, we investigated if and how the cAMP/PKA-mediated signalling influences the aggregation state of the respiratory complexes. An analysis of the inhibitory titration profiles of the endogenous oxygen consumption rates in intact HepG2 cells with specific inhibitors of the re

SUBMITTER: Scrima R 

PROVIDER: S-EPMC10607245 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature